Rescan of 27 open safety axes leaves 22 in explicit uncertainty; only 3 resolve to lower concern and 2 to conditional restriction

Asked (summary):

Project ATLAS / ASTRA — independent from-scratch rescan of 27 unresolved safety & usage axes (search date 2026-09-14) for Tridecyl Trimellitate, Vitis Vinifera (Grape) Seed Oil, and Red 7 Lake / D&C Red No. 7 Lake / CI 15850:1. Research only the 27 named axes; do not reopen locked axes. Return a concise ingredient-by-axis report and downloadable strict JSON (contract atlas-keenable-independent-27-axis-rescan-v1) with primary sources, exact identities, direct URLs and exact locators.

The adjudication covers all 27 requested material-axis pairs — 27 of 27, no locked axes reopened — across three cosmetic ingredients, drawing on primary sources from CIR, Health Canada/ECCC, FDA/eCFR, ECHA and original peer-reviewed literature. Uncertainty is not evidence of harm: it means exact-material, endpoint-specific evidence was insufficient, and broad cosmetic safety conclusions were deliberately not used as unsupported safe defaults for cancer, endocrine, pregnancy, lactation, teen, reproductive-developmental or environmental endpoints.

Disposition matrix — 3 materials × 11 axes

Lower concern (teal) — resolved, narrowly conditioned Conditional restriction (yellow) — resolved only within stated conditions Explicit uncertainty (yellow) — exact-material evidence insufficient Not in this rescan (locked or not requested)

Hover or tap a cell for rationale, source and remaining prerequisite.

Download strict JSON — atlas-keenable-independent-27-axis-rescan-v1

Tridecyl Trimellitate's only resolved axis is environmental: Canada's screening assessment concluded low risk of ecological harm for TTDT/BTIT — canada.ca

Grape seed oil's sensitive-skin axis stays uncertain despite CIR's favorable present-use conclusion, because no exact-oil study resolves oxidation products or residual seed protein — cir-safety.org

Red 7 Lake's general safety is a conditional restriction: permanently listed under 21 CFR 74.1307 with batch certification, GMP amounts, no eye-area use and a 0.015% impurity cap — hfpappexternal.fda.gov

Red 7 Lake's reproductive-developmental axis remains uncertain: a 30-day oral study at 1000 mg/kg/day with reversible kidney/body-weight findings cannot resolve fertility or prenatal development — pubmed.ncbi.nlm.nih.gov

Disposition summary

Exact identities and corrections

Tridecyl TrimellitateThe triester — tristridecyl trimellitate — associated with CAS 94109-09-8. Distinguish from the mixed branched tridecyl/isodecyl material (BTIT) used in some authority read-across, including Canada's environmental screening.

Vitis Vinifera (Grape) Seed OilSeed-derived triglyceride oil — not whole grape, grape-seed extract, monoacylglycerides or an isolated constituent. CIR did not pin down every extraction/refining, oxidation or contaminant condition, so those become product prerequisites.

Red 7 Lake / CI 15850:1The calcium salt C.I. Pigment Red 57:1, commonly associated with CAS 5281-04-9. An FDA-certified lake additionally requires a permitted substratum and batch certification; the inspected evidence did not establish one universal substrate for every commercial lake, so the certificate/lot specification is a product prerequisite. Evidence from the free acid, sodium salt, other lakes or unverified historical grades is not transferred.

One scope difference is noted, not a contradiction: Red 7's high-dose oral study reported reversible kidney and body-weight findings, while regulatory listing and limited dermal evidence are favorable — different routes, doses and questions. The two lower-concern irritation calls remain narrowly conditioned: grape seed oil only as compositionally specified, non-oxidized oil within CIR present-use scope, and Red 7 only as the exact certified calcium lake, dermal route, GMP amount, no eye-area use, permitted substrate and compliant impurities. Neither implies sensitive-skin resolution.

Evidence table — all 27 axis records

Material	Axis	Disposition	Rationale / conditions	Remaining prerequisite	Authority · locator	Source

Method: independent from-scratch rescan, search date 2026-09-14, contract atlas-keenable-independent-27-axis-rescan-v1. 27 rows, one per requested material-axis pair (27/27 covered; 0 locked axes repeated; 0 duplicates), each with disposition, rationale, prerequisite, applicability conditions, primary-source URL and exact locator. Four adjudications were corrected to conservative dispositions (grape seed oil sensitive_skin and use_restriction; Red 7 sensitive_skin and developmental_reproductive_toxicity). Dispositions measure whether exact-material, endpoint-specific primary evidence resolves each axis — not risk magnitude. Full qualified conclusions and limitations were shortened for space; the downloadable JSON carries them in full.

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