Project ATLAS / ASTRA — SKIN1004 scientific closeout, 15 September 2026. Perform a bounded, gap-only scientific review of 25 exact current materials and 255 unresolved axes, preserving exact material boundaries and already-resolved axes; return scoped statuses, applicability conditions, exact missing prerequisites, and fully documented findings from primary authorities or original studies.
The bounded search on 15 September 2026 retrieved 598 candidate records — 12 tightly filtered authority provisions, 180 original-study and government-toxicology rows, and 406 botanical identity and study leads — spanning CIR and PubMed/NCBI hosts. Most rows are near-neighbor analogues or efficacy leads, not exact-material findings; individual CIR conclusions here may be single-sourced. This is a scientific gap review, not a blanket product-safety judgment.
Each bar is the retrieved record count per material family (square-root axis). Colour is boundary status, not volume: only green families yielded exact usable records. Hover or tap a bar for the actual retrieved material names behind it.
The small subset where retrieved evidence matches the requested material tightly enough to state a scoped status.
9 butter, oil and glyceride ingredients concluded safe as used in present practices of use and concentration; 4 nut and seedcake ingredients insufficient to determine safety. Shea oil is US GRAS as a direct food additive (21CFR§184.1702). cir-safety.org
No reactions to acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol) 2% aq.; sodium polyacrylate 2% aq. gave one positive of unknown relevance. Grade and residual-monomer identity for the requested polymer remain open. pubmed.ncbi.nlm.nih.gov
Panel concluded phytosterols safe as cosmetic ingredients in the practices of use and concentration of the assessment; the retrieved copy is the 2013 tentative report for public comment. cir-safety.org
A CIR table records lauric acid (CAS 143-07-7) as previously reviewed "Safe" (JACT 1987; re-reviewed, not reopened, 2006). Finished-product concentration in the requested formula is unknown. cir-safety.org
25% and 50% topical solutions over 4 weeks: dermatitis in 1 patient at 25% and 3 at 50% (one withdrawn). Concentrations exceed leave-on cosmetic use; oxidation state and chemotype unreported. pubmed.ncbi.nlm.nih.gov
The 2023 CIR hyaluronates sheet notes 7 hyaluronate names are not restricted under EU cosmetic rules — non-restriction, not clearance. Molecular weight and CAS of the hydrolyzed grade stay ambiguous. Single-sourced. cir-safety.org
Why most of the 255 requested axes stay evidence-insufficient even where records exist.
All 12 authority rows plus the 63 study rows in exact or tightly scoped families; the 406 botanical leads and remaining analogue rows are summarized in the chart above.
| Type | Retrieved material | Provision / result | Scope / endpoint | Source |
|---|
Method: bounded gap-only review for the SKIN1004 25-material closeout, search date 2026-09-15. 598 retrieved rows — 12 filtered authority/regulatory provisions, 180 original-study/government-toxicology candidates, 406 botanical identity/assessment/study leads — from CIR and PubMed/NCBI hosts. Bars count retrieved records per material family, not evidence quality; colour marks boundary status. Individual CIR conclusions may be single-sourced. Analogue and efficacy rows are shown as coverage only and were cut from the table for space; non-listing, food-use status and near-neighbor evidence are not clearance for a requested different material.